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Imputation of fluid intelligence scores reduces ascertainment bias and increases power for analyses of common and rare variants
2025-06-20
genetic and genomic medicine
Title + abstract only
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Studying the genetics of measures of intelligence can help us understand the neurobiology of cognitive function and the aetiology of rare neurodevelopmental conditions. The largest previous genetic studies of measures of intelligence have used [~]270k individuals who completed the fluid intelligence (FI) test in UK Biobank. Here, we integrate additional FI measures in this cohort and leverage eighty-two correlated variables to impute FI values for unmeasured individuals, increasing the sample si...
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