MODY is prevalent in later-onset diabetes, has potential for targeted therapy but is challenging to identify

2025-06-18 endocrinology Title + abstract only

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Maturity Onset Diabetes of the Young (MODY) can present after the age of 40yrs, but its prevalence, clinical characteristics, and the utility of simple clinical features for selecting cases in this age group remain poorly defined. We analysed whole-exome and clinical data from 51,619 individuals with diabetes diagnosed after 40 years of age from two large cohorts: the UK Biobank (n = 25,012) and the US health system MyCode cohort (n = 26,607). The prevalence of MODY due to pathogenic variants in...

MODY is prevalent in later-onset diabetes, has potential for targeted therapy but is challenging to identify

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