Machine Learning Models Enhance Prediction of Arrhythmogenic Right Ventricular Cardiomyopathy
Quansah, K. K.; Murphy, S. A.; Kwon, E.; Anderson, E.; Carrick, R. T.; James, C. A.; Calkins, H.; Kwon, C.
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Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a leading contributor to sudden cardiac death worldwide in young adults, yet its diagnosis remains complex, expensive and time-consuming. Machine-learning (ML) classifiers offer a practical solution by delivering rapid, scalable predictions that can lessen dependence on expert interpretation and speed clinical decision-making. Here, we benchmarked six ML algorithms for ARVC detection using area-under-the-curve (AUC) and accuracy as primary metrics. Gradient Boosted Trees outperformed all other models, achieving a c-statistic of 94.34% after rigorous cross-validation. These results underscore the promise of Gradient Boosted Trees classifier as an effective decision-support tool within the ARVC diagnostic workflow, with potential to streamline evaluation and improve patient outcomes.
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