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Evaluation of the evolution of SARS-CoV-2 Omicron variant and the spreading of LP.8.1 and NB.1.8.1

Yi, B.

2025-06-17 epidemiology
10.1101/2025.06.16.25329694 medRxiv
Show abstract

Till now our understanding about the trend of evolution and spreading of SARS-CoV-2 is still limited. The fast spreading of newly emerging Omicron variants LP.8.1 and NB.1.8.1 has brought many questions regarding the evolution course and spreading trend. In this study we analyzed the evolutionary relationship among representative Omicron subvariants, and investigated spreading trend by analyzing the relative growth advantage of the newly emerging Omicron variants LP.8.1 and NB.1.8.1. The results have revealed a modest relative growth advantage of LP.8.1, and one much larger relative growth advantage of NB.1.8.1 over co-circulating BA.2.86/JN.1 subvariants including LP.8.1, indicating that NB.1.8.1 will possibly become the next dominant variant worldwide. As NB.1.8.1 is a product of intricate evolutionary events, the spreading of this variant would further complicate the prediction about future evolution and spreading trend of the SARS-CoV-2, highlighting the importance and necessity of performing genomic surveillance and monitoring SARS-CoV-2 evolution.

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