Independent serum metabolomics approaches identify disrupted glutamic acid and serine metabolism in Parkinson's disease patients
Gervasoni, J.; Marino, C.; Imarisio, A.; Santucci, L.; Napolitano, E.; Nuzzo, T.; Yahyavi, I.; Avenali, M.; Cicchinelli, M.; Buongarzone, G.; Galandra, C.; Picascia, M.; Grimaldi, M.; Pacchetti, C.; Errico, F.; D'Ursi, A. M.; Urbani, A.; Valente, E. M.; Usiello, A.
Show abstract
Previous studies assessing blood metabolomic profiles in Parkinsons disease (PD) patients showed inconsistent results. Here, we employed {superscript 1}H-NMR and UPLC/MS analyses on serum samples from a cohort of PD patients and healthy controls (HC). Compared to HC, PD patients showed: (i) higher glutamine, serine, pyruvate and lower -ketoglutarate levels (1H-NMR); (ii) higher glycine and lower glutamic acid concentrations (UPLC/MS). Several pathways associated with amino acids, mitochondrial and antioxidant metabolism emerged as dysregulated in PD. Our findings highlight a prominent disruption of cellular bioenergetic pathways and amino acid homeostasis in PD.
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