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Pre-analytical delay of blood cultures which hinders the management of sepsis and fosters the emergence of antimicrobial resistance is an adverse effect of laboratory centralisation.
2025-06-11
infectious diseases
Title + abstract only
View on medRxiv
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BackgroundThe clinical diagnosis of sepsis is based on non-specific criteria and blood culture remains the gold standard confirmatory test. While early results are of wide clinical benefit delayed reports lead to prolonged anti-microbial therapy which fosters the emergence of antimicrobial resistance. Pre-analytical delay of a blood culture delays or decreases the chance of a positive report and a maximal four-hour delay between collection and incubation of the specimen is recommended by the Uni...
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