Delayed Negative Symptom Response to Antipsychotics: An Individual Participant Data Analysis
Leucht, S.; Harrer, M.; Illing, S.; Levine, S. Z.
Show abstract
This protocol outlines an individual participant data (IPD) analysis investigating the temporal dynamics of schizophrenia symptoms during antipsychotic treatment. Using harmonized data from six antipsychotic drug trials, we aim to examine weekly trajectories of Positive and Negative Syndrome Scale (PANSS) sub-scores over a 26-week period. Our aim is to determine whether reductions in positive symptoms precede and predict improvements in negative symptoms. To this end, will conduct (i) descriptive analyses, showing the trajectories of five PANSS sub-scores over time; (ii) test potential a "delay" until response in negative symptoms (versus positive symptoms) is reached; and (iii) examine if improvements in positive symptoms predict changes in negative symptoms one week ahead.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Moderate to severe negative symptoms predict low risk of symptoms worsening in schizophrenia patients in CATIE 95%
- Blink rates in patients with schizophrenia compared to healthy controls: A meta-analysis 94%
- Dopamine D1 receptor availability is not associated with delusional ideation measures of psychosis proneness 92%
Similar papers in this journal
- Antipsychotic Polypharmacy and Adverse Drug Reactions Among Adults in a London Mental Health Service, 2008-2018 93%
- Relapse prevention through health technology program reduces hospitalization in schizophrenia 92%
- Developmental Influences on Symptom Expression in Antipsychotic-Naive First-Episode Psychosis 91%
Similar papers in this journal
- Study protocol for the development and internal validation of SPIRIT (Schizophrenia Prediction of Resistance to Treatment): A clinical tool for predicting risk of treatment resistance to anti-psychotics in First Episode Schizophrenia 94%
- Side effect profile and comparative tolerability of newer generation antidepressants in the acute treatment of major depressive disorder in children and adolescents: protocol for a systematic review and network meta-analysis 92%
- Global prevalence of antidepressant utilization in the community: A protocol for a systematic review 90%
Similar papers in this journal
- Examining side effect variation of antipsychotic treatment in schizophrenia spectrum disorders 94%
- Comparative efficacy and acceptability of treatment strategies for antipsychotic-induced akathisia: a systematic review and network meta-analysis 93%
- Neurovascular Uncoupling in Schizophrenia: A Bimodal Meta-Analysis of Brain Perfusion and Glucose Metabolism 92%
Similar papers in this journal
- Progressive changes in descriptive discourse in First Episode of Schizophrenia: A longitudinal computational semantics study 92%
- Clozapine prescribing in Germany: temporal trends and regional variations, 2012 to 2022 92%
- Mediation and Longitudinal Analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.