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Development and validation of a Trans-Ancestry polygenic risk score for Type 1 Diabetes
2025-06-09
endocrinology
Title + abstract only
View on medRxiv
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ObjectivesThe high heritability of type 1 diabetes has enabled the development of polygenic risk scores (PRS) as disease risk screening tools. PRS can identify individuals at the highest genetic risk in a population, who can benefit from autoantibody and metabolic surveillance, to avoid ketoacidosis at diagnosis and access preventive therapies. However, PRS for type 1 diabetes developed from European data perform less well in non-European ancestries. We aimed to develop a PRS with comparable per...
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