Pervasive Intraspecific Genetic Local Adaptation Within the Natural Gut Microbiome
Jasper, R.; Kapopoulou, A.; Peischl, S.; Yilmaz, B.; Becker, J.; Bank, C.
Show abstract
Gut microbial communities are shaped by the physicochemical gradients and compartmentalization along the gastrointestinal tract. Whether spatially variable selection is strong enough to promote lasting genetic divergence within microbial species subject to migration and clonal expansion remains unclear. We performed a metagenomic population-genetic analysis of roe deer microbiota across metabolically and structurally distinct gut compartments. Remarkably, 10 of 20 prevalent bacterial species exhibited clear signatures of genetic local adaptation, despite the homogenizing effects of frequent migration. Nutrient availability and environmental stability emerged as primary drivers of selection, with horizontal gene transfer as a key mechanism enabling local adaptation. Our findings demonstrate that a comprehensive understanding of ecological and evolutionary dynamics in the gut necessitates considering fine-scale genetic variation within species.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Improved eukaryotic detection compatible with large-scale automated analysis of metagenomes 95%
- Viruses contribute to microbial diversification in the rumen ecosystem and are associated with certain animal production traits. 95%
- Microbial context predicts SARS-CoV-2 prevalence in patients and the hospital built environment 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.