Identification of chaperone-independent outer membrane proteins and MtrA-assisted MtrB folding in Shewanella oneidensis
Kneuer, L.; Siebels, B.; Marin, L.; Philipp, L.-A.; Gescher, J.
Show abstract
Extracellular electron transfer is a respiratory process conducted by a number of microorganisms in order to access insoluble or membrane impermeable electron acceptors or donors. The process has wide implication for the biogeochemistry of our planet and offers many opportunities for biotechnological applications. Outer membrane spanning electron transfer is conducted by the model organism Shewanella oneidensis MR-1 by a stable trimeric protein complex. The electron conduit consists of two c-type cytochromes on either site of the outer membrane and a {beta}-barrel protein in the middle that seems to facilitate interaction of the two heme containing proteins. This study reveals that the periplasmic c-type cytochrome MtrA is not only part of the electron conduit, but also assists in the periplasmic transport of the unfolded outer membrane protein MtrB, a function that was so far believed to be conducted for all outer membrane {beta}-barrel proteins by one of the canonical chaperones SurA, Skp or DegP. However, three more {beta}-barrel proteins were identified that are independent of the canonical chaperones as well but still rely on the BAM complex in the outer membrane, suggesting that many more solutions for periplasmic transfer of {beta}-barrel protein towards the outer membrane exist in Gram-negative microorganisms.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A novel pH-regulated, unusual 603 bp overlapping protein coding gene pop is encoded antisense to ompA in Escherichia coli O157:H7 (EHEC) 94%
- Pectin induced colony expansion of soil-derived Flavobacterium strains 93%
- A TetR-family protein activates transcription from a new promoter motif associated with essential genes for autotrophic growth in acetogens 93%
Similar papers in this journal
- The type VII secretion system protects Staphylococcus aureus against antimicrobial host fatty acids 94%
- The potential for polyphosphate metabolism in Archaea and anaerobic polyphosphate formation in Methanosarcina mazei. 94%
- Iron acquisition system of Sphingobium sp. strain SYK-6, a degrader of lignin-derived aromatic compounds 94%
Similar papers in this journal
- Pseudomonas aeruginosa MipA-MipB envelope proteins act as new sensors of polymyxin 95%
- Analysis of the oxidative stress regulon identifies soxS as a genetic target for resistance reversal in multi-drug resistant Klebsiella pneumoniae 94%
- FhaA plays a key role in mycobacterial polar elongation and 1 asymmetric growth 94%
Similar papers in this journal
- Quantitative physiology and proteome adaptations of Bifidobacterium breve NRBB57 at near-zero growth rates 94%
- Lysis cassette-mediated exoprotein release in Yersinia entomophaga is controlled by a PhoB-like regulator 94%
- Characterization of TelE, an LXG effector exhibiting a conserved C-terminal glycine zipper motif required for toxicity 94%
Similar papers in this journal
- Protein Interactomes Identify Distinct Pathways for Streptococcus mutans YidC1 and YidC2 Membrane Protein Insertases 94%
- The cysteine-rich exosporium morphogenetic protein, CdeC, exhibits self-assembly properties that lead to organized inclusion bodies in Escherichia coli 94%
- The role of FraI in cell-cell communication and differentiation in the hormogonia-forming cyanobacterium Nostoc punctiforme 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.