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Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress

2025-06-06 psychiatry and clinical psychology Title + abstract only
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Posttraumatic stress disorder (PTSD) has been associated with altered arousal regulation and dysfunction of the hypothalamic-pituitary-adrenal axis, including changes in circulating cortisol and pituitary adenylate cyclase-activating polypeptide (PACAP). Both stress-related hormones affect extended amygdala to medial prefrontal cortex (mPFC) circuit functioning, but it is unclear whether they relate to white matter microstructure connecting these regions. We examined this question in 139 trauma-...

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