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The architecture of exposome-phenome associations
2025-06-06
epidemiology
Title + abstract only
View on medRxiv
Show abstract
Non-genetic exposures comprising the "exposome," including diet, lifestyle, infections, and pollutants, shape many clinical phenotypes, yet the evidence remains fragmented. We conducted an Exposome-Wide Association study (ExWAS) incorporating 619 exposure indicators and 305 quantitative phenotypes across 10 independent waves of the US Centers for Disease Control and Prevention National Health and Nutrition Examination Survey (CDC NHANES). Replicable and stable signals were most concentrated in c...
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