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GPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection

Yang, M.; Bian, F.; Feng, X.; Li, L.; Huang, H.; Liu, L.; Dalal, R.; Yang, H.; Suraparaju, P. V.; Cao, F.; Ong, P.; Luo, A.; Liu, D.; Hu, Y.

2025-06-06 neuroscience
10.1101/2025.06.03.657677 bioRxiv
Show abstract

Preventing retinal ganglion cells (RGCs)s soma and axon degeneration and promoting optic nerve (ON) regeneration holds great promise for effective glaucoma treatment. To explore potential neural repair strategies, we focused on glutathione peroxidase 4 (GPX4), a key regulator of lipid peroxidation. GPX4 is upregulated in surviving RGCs after acute ON crush or chronic ocular hypertension insult, and also in regenerating RGCs. AAV-mediated RGC-specific overexpression of GPX4 promotes significant ON regeneration and RGC survival, along with visual functional preservation, demonstrating the detrimental role of lipid peroxidation in glaucoma and the therapeutic potential of modulating lipid peroxidation through GPX4 in optic neuropathies.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.