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Immunogenomic landscape of T cell repertoire after human lung transplantation and its clinical significance
2025-06-04
transplantation
Title + abstract only
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Despite advances in surgical techniques and immunosuppression, long-term survival after lung transplantation (LuTx) remains suboptimal due to high rates of rejection, infection and graft dysfunction. To address this, we investigated post-LuTx T cell dynamics--tracking repopulation, clonal distribution, alloreactivity, and microbial reactivity--through flow cytometry and TCR{beta} sequencing of serial bronchoalveolar lavage (BAL) and peripheral blood samples. Pre- transplant mixed lymphocyte reac...
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