eyeris: A flexible, extensible, and reproducible pupillometry preprocessing framework in R

Pupillometry provides a non-invasive window into the mind and brain, particularly as a psychophysiological readout of autonomic and cognitive processes like arousal, attention, stress, and emotional states. Pupillometry research lacks a robust, standardized framework for data preprocessing, whereas in functional magnetic resonance imaging and electroencephalography, researchers have converged on tools such as fMRIPrep, EEGLAB and MNE-Python; these tools are considered the gold standard in the field. Many established pupillometry preprocessing packages and workflows fall short of serving the goal of enhancing reproducibility, especially since most existing solutions lack designs based on Findability, Accessibility, Interoperability, and Reusability (FAIR) principles. To promote FAIR and open science practices for pupillometry research, we developed eyeris, a complete pupillometry preprocessing suite designed to be intuitive, modular, performant, and extensible (https://github.com/shawntz/eyeris). Out-of-the-box, eyeris provides a recommended preprocessing workflow and considers signal processing best practices for tonic and phasic pupillometry. Moreover, eyeris further enables open and reproducible science workflows, as well as quality control workflows by following a well-established file management schema and generating interactive output reports for both record keeping/sharing and quality assurance of preprocessed pupil data prior to formal analysis. Taken together, eyeris provides a robust all-in-one transparent and adaptive solution for high-fidelity pupillometry preprocessing with the aim of further improving reproducibility in pupillometry research. Impact StatementPupillometry research currently lacks a standardized, integrated preprocessing framework comparable to tools widely adopted in EEG and fMRI research. We introduce eyeris, an open-source R package that fills this gap through a modular, transparent pipeline with signal processing best practices, interactive diagnostic reports for quality control, and scalable database storage. eyeris advances pupillometry methods by promoting reproducible, FAIR-compliant workflows accessible to researchers at all levels of programming expertise.