The MagMa Study: Quantum Magnetocardiography in Non-Ischemic Cardiomyopathy

BackgroundRapid diagnostic screening is an unmet need in patients with suspected cardiomyopathy. We recently demonstrated that magnetocardiography (MCG) might be a suitable tool to detect cardiomyopathies. We now tested diagnostic accuracy of MCG prospectively. MethodsMCG uses a superconducting quantum interference device (SQUID) to detect the electromagnetic field of the heart. In our recent retrospective study, a T-beg-Tmax (MCG Score) > 0.051 identified patients with non-ischemic cardiomyopathy. We assessed the diagnostic accuracy of MCG compared to advanced imaging and/or endomyocardial biopsy (EMB). Results from EMB took precedence over advanced imaging. We enrolled 110 patients with angina-like symptoms after exclusion of coronary artery disease (Power calculation: Expected 80% power at a 5% significance level) from the emergency department, in-patient wards and outpatient clinics. Exclusion criteria included presence of intracardiac metal devices and treatment with immunosuppressants. We incorporated 220 healthy individuals using 1:2 propensity score matching (age, sex) for a total of 330 participants. ResultsMCG detected cardiomyopathy with 94.74% sensitivity (95% CI: 85-99%), 98.54% specificity (95% CI: 96-100%), 93.1% negative predictive value (NPV, 95% CI: 84-98%) and 94.34% positive predictive value (PPV, 95% CI: 84-98%). In 3 patients, CMR failed to detect non-ischemic cardiomyopathy, whereas MCG showed pathological results consistent with results of EMB. Results were highly reproducible (statistical uncertainty: 2.5%, T-beg-Tmax (MCG Score) +/- 0.004). ConclusionMCG offers a non-invasive, reproducible methodology for rapid and accurate detection of non-ischemic cardiomyopathy. Our data indicate that MCG may be an efficient tool for allocation of advanced imaging to those in greatest need. Visual Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=138 SRC="FIGDIR/small/25328567v1_ufig1.gif" ALT="Figure 1"> View larger version (43K): org.highwire.dtl.DTLVardef@9fd887org.highwire.dtl.DTLVardef@40af64org.highwire.dtl.DTLVardef@baff9aorg.highwire.dtl.DTLVardef@e2f388_HPS_FORMAT_FIGEXP M_FIG C_FIG