Chorionic Gonadotropin Beta 7 is a marker of immune evasion in cancer
McKellar, S. A.; Pineda, J. M. B.; Lattupally, R.; Codd, A. S.; Newell, E.; Lu, S. X.; Bradley, R. K.
Show abstract
Human chorionic gonadotropin beta (beta-hCG) is an oncofetal antigen expressed by trophoblast cells of the placenta, with minimal expression in adult somatic tissues. Numerous studies have demonstrated that beta-hCG-encoding genes are expressed in various cancers, but expression of these genes (CGB3, CGB5, CGB7, and CGB8) across diverse cancers has not been systematically evaluated. Here, we report that CGB genes are more widely expressed across diverse cancer types than previously appreciated and that secreted beta-hCG is readily detected. In particular, CGB genes are expressed in the majority of urothelial bladder cancers, where CGB7 is most frequently expressed and significantly associated with an immunosuppressed tumor microenvironment, including decreased CD8+ T cell infiltration. Multiple CGB genes are associated with failure to respond to immune checkpoint inhibitor (ICI) therapy, and CGB7 is particularly strongly predictive of poor prognosis. Overall, our findings indicate that beta-hCG is a clinically accessible, predictive biomarker of immunotherapeutic response.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells 96%
- Evolutionary states and trajectories characterized by distinct pathways stratify ovarian high-grade serous carcinoma patients 96%
- Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer 95%
Similar papers in this journal
- DUX4 is a common driver of immune evasion and immunotherapy failure in metastatic cancers 96%
- Co-regulation and functional cooperativity of FOXM1 and RHNO1 bidirectional genes in ovarian cancer 95%
- An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma 95%
Similar papers in this journal
- Single-cell Transcriptomics Identifies Gene Expression Networks Driving Differentiation and Tumorigenesis in the Human Fallopian Tube 96%
- G9a Promotes Breast Cancer Recurrence Through Repression of a Pro-inflammatory Program 96%
- Mapping the tumor stress network reveals dynamic shifts in the stromal oxidative stress response 95%
Similar papers in this journal
- Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes 94%
- Genome profiles of lymphovascular breast cancer cells reveal multiple clonally differentiated outcomes with multi-regional LCM and G&T-seq 94%
- An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.