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Extensive Intra-host evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host

2025-05-28 allergy and immunology Title + abstract only
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Persistent SARS-CoV-2 infection in immunocompromised patients creates a unique environment for the accumulation of mutations linked to immune evasion. This is due to prolonged virus-host interaction, coupled with the effects of diminished selective pressures resulting from suboptimal adaptive immunity. In this study, we investigated viral evolution and immune escape during a 2.5-year persistent SARS-CoV-2 infection in a patient with a history of multiple myeloma and rheumatoid arthritis on B ce...

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