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A deep cellular atlas of the human ventral substantia nigra in Parkinson's identifies a genetic and molecular overlap with Type 2 Diabetes
2025-05-28
neurology
Title + abstract only
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Parkinsons disease (PD) is a complex neurodegenerative disorder characterised by selective neuronal loss. We integrate deep full-length single-nuclei sequencing of the human substantia nigra with novel genome-wide association studies (GWAS) identifying genetic and cellular drivers of PD. Genetic risk converges on AGTR1+ dopaminergic neurons and perineuronal oligodendrocytes (pODCs), both reduced in PD, as well as oligodendrocyte precursor cells, enriched among disease-disrupted intercellular int...
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