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Genomic investigation of increased incidence of disseminated gonococcal infections cases in Minnesota, USA, 2024

Evans, D.; Friedlander, H.; Bo-Subait, K.; Dennis, J.; Kaiyalethe, J.; Craft, B.; Plumb, M.; Bohnker-Voels, L.; Pung, K.; Mondelli, A.; Garfin, J.; Zipprich, J.; Snippes-Vagnone, P.; Como-Sabetti, K.; Lynfield, R.

2025-05-29 infectious diseases
10.1101/2025.05.27.25328426 medRxiv
Show abstract

We summarize a genomic investigation of a 4-fold increase in disseminated gonococcal infections (DGI) in Minnesota, USA, in 2024. We detected the emergence of strain of Neisseria gonorrhoeae of a rarely observed sequence type, which carries a porB1a allele previously associated with disseminated disease and lacks a gonococcal genetic island. Article Summary LineA substantial increase in disseminated gonococcal infection cases in Minnesota, USA in 2024 was associated with the emergence of a rarely observed sequence type of Neisseria gonorrhoeae.

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