The influence of nucleus accumbens shell D1 and D2 neurons on outcome-specific Pavlovian instrumental transfer
Soegyono, O.; Pepin, E.; Leung, B. K.; Chieng, B.; Balleine, B. W.; Laurent, V.
Show abstract
The nucleus accumbens shell (NAc-S) and its projections to the ventral pallidum (VP) are thought to be critical for stimulus-based decisions. The NAc-S is predominantly composed of spiny projection neurons (SPNs) that express either the dopamine D1 (D1-SPNs) or the dopamine D2 receptor (D2-SPNs). Yet, the role of these two neuronal subpopulations and their inputs to the VP in stimulus-based decisions remains unknown. Here, we used optogenetics in female and male knock-in rats to selectively silence D1-or D2-SPNs and their projections to the VP at a time when the rats were required to use predictive stimuli to choose between two instrumental actions. Silencing either population of NAc-S SPNs disrupted choice. Silencing NAc-S D1-SPNs terminals in the VP also disrupted choice. However, choice was left intact by silencing NAc-S D2-SPNs terminals in the VP. Together, these findings provide novel insights into the cellular mechanisms and circuitry underlying stimulus-based decisions. We discuss how these insights are consistent with a recent model proposing that these decisions are controlled by an opioid-based memory system residing in the NAc-S.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- The Paraventricular Thalamus is a Critical Mediator of Top-down Control of Cue-motivated Behavior in Rats 98%
- Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens 97%
- Dopamine in the Dorsal Bed Nucleus of Stria Terminalis signals Pavlovian sign-tracking and reward violations 97%
Similar papers in this journal
- The role of genetically distinct central amygdala neurons in appetitive and aversive responding assayed with a novel dual valence operant conditioning paradigm. 97%
- Role of the nucleus accumbens in signaled avoidance actions 96%
- Retrograde labeling illuminates distinct topographical organization of D1 and D2 receptor-positive neurons in the prefrontal cortex of mice 96%
Similar papers in this journal
- Dense cortical input to the rostromedial tegmental nucleus mediates aversive signaling 97%
- Galanin receptor 1 expressing neurons in hippocampal-prefrontal circuitry modulate goal directed attention and impulse control 96%
- Independence of Cued and Contextual Components of Fear Conditioning is Gated by the Lateral Habenula 96%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.