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Transcriptional and translational genetic control in blood contributes significantly to complex trait heritability and polygenic prediction
2025-05-25
genetic and genomic medicine
Title + abstract only
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Genetic variants can influence complex traits by regulating gene products such as gene expression, RNA splicing, and protein abundance. While molecular quantitative trait loci (molQTL) are widely leveraged to infer causal genes, their overall contribution to complex trait variation remains unclear. Here, we systematically evaluate the contributions of expression (eQTL), splicing (sQTL), and protein (pQTL) QTL in blood to SNP-based heritability and polygenic prediction across 27 complex traits. U...
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