An oncolytic herpesvirus expressing a CXCR4 antagonist interferes with Glioblastoma cells stemness features and migration.
D'ARRIGO, P.; DUBOIS, M.; SANCHEZ GIL, J.; LASSENCE, C.; BROUWERS, B.; LOMBARD, A.; ROGISTER, B.; NEIRINCKX, V.; LEBRUN, M.; SADZOT-DELVAUX, C.
Show abstract
Glioblastoma is one of the most aggressive brain tumors. Despite the standard therapy, the survival from diagnosis remains dramatically low, especially due to relapses. Considering their capacity to escape the tumor and to migrate to the subventricular zone through a CXCR4-dependant mechanism, Glioblastoma stem-like cells (GSCs) are considered as responsible for these relapses. CXCR4 regulates biological features associated with tumor progression, including self-renewal, migration and radio-resistance. Importantly, its expression correlates with severity and poor prognosis of several cancers including GBM. CXCR4/CXCL12 pathway appears therefore as an interesting potential therapeutic target. We have generated an oncolytic herpesvirus (oHSV) expressing HA-P2G, a mutated form of CXCL12 previously described as a CXCR4 competitive inhibitor. We demonstrate that in vitro, oHSV/P2G impairs human primary GSCs stemness markers expression, self-renewal and migration. In an orthotopic xenograft murine model, its injection within the tumor limits tumor growth and GSCs migration. The ability of P2G to interfere with major GSC features demonstrates the interest in considering oHSV/P2G as a promising new therapeutic approach for glioblastoma patients.
Matching journals
The top 12 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts 96%
- GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence 95%
- GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior 93%
Similar papers in this journal
- Tumor expressed CD95 causes suppression of anti-tumor activity of NK cells in a model of triple negative breast cancer 93%
- Versatile roles of Annexin A4 in ccRCC: impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment 93%
- The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.