Diagnostic Accuracy in Predicting the Clinical Diagnoses of Parkinson Disease, Parkinson Disease with Dementia and Dementia with Lewy Bodies Using Skin Biopsies Analyzed with alpha-Synuclein Seed Amplification Assays

2025-05-22 neurology Title + abstract only

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Skin biopsies of patients with parkinsonism, mild cognitive impairment or dementia might offer a simple and relatively non-invasive means to determine whether -synuclein aggregates might be the underlying pathology. Accurate biomarkers are critically needed for Lewy body disease (LBD) clinical trials but currently there are none that have undergone full regulatory scrutiny. We sought to simulate the rigor of a diagnostic study done with regulatory oversight in this study of the accuracy of skin...

Diagnostic Accuracy in Predicting the Clinical Diagnoses of Parkinson Disease, Parkinson Disease with Dementia and Dementia with Lewy Bodies Using Skin Biopsies Analyzed with alpha-Synuclein Seed Amplification Assays

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