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Obesity's Disparate Impact on COVID-19 Outcomes in Asian American Patients with Cancer

Nguyen, R. H.; Shah, P. K.; Mishra, S.; Fu, J.; Reid, S. A.; Hawley, J. E.; Hwang, C.; Singh, S. R.; Gatson, N. T.; Florez, N.; Chism, D.; Serrano, O. K.; Bashir, B.; Nagaraj, G.; McKay, R. R.; Hayes-Lattin, B.; Koshkin, V. S.; Acoba, J. D.; Zamulko, O.; Geiger, C. L.; Warner, J. L.; Shah, D. P.; Venepalli, N. K.

2025-05-16 oncology
10.1101/2025.05.14.25327577 medRxiv
Show abstract

Data on COVID-19 outcomes in Asian Americans and Pacific Islanders (AAPI) are lacking. We analyzed data from 6,244 patients from the COVID-19 and Cancer Consortium, including 6.0% AAPI patients, to examine disparities in outcomes following acute COVID-19. Despite AAPI patients having lower median BMI than non-Hispanic White (NHW) patients and higher diabetes rates, both groups showed similar 30-day mortality and COVID-19 outcomes. In multivariable analyses, morbid obesity (BMI >35 kg/m2) in AAPI patients was associated with significantly higher 30-day mortality (OR 4.96; 95% CI 1.78 - 13.88) and COVID-19 severity (OR 2.6; 95% CI 1.26 - 5.35); underscoring the differential impact of obesity in AAPI patients.

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