SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice
Mashiko, D.; Tonai, S.; Miyata, H.; Matzuk, M.; Ikawa, M.
Show abstract
Despite the recognized importance of glycans in biological phenomena, their complex roles in spermatogenesis and sperm function remain unclear. SLC35G3, a 10-transmembrane protein specifically found in early round spermatids, belongs to the sugar-nucleotide transporter family, indicating its involvement in glycan formation. In this study, we found that Slc35g3 knockout male mice were sterile due to impaired sperm functions in uterotubal junction passage, zona pellucida binding, and oocyte fusion. Mouse SLC35G3 has UDP-GlcNAc transporter activity, and its ablation caused abnormal processing of the sperm plasma membrane and acrosome membrane proteins. Reported human SLC35G3 mutations (F267L and T179HfsTer27) diminished the UDP-GlcNAc transporter activity of SLC35G3, implying infertility risks in males carrying these mutations. Our findings unveil the vital roles of SLC35G3 in the glycan formation of sperm membrane proteins critical for sperm fertilizing ability.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking 96%
- YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiation 96%
- MRP5 and MRP9 Play a Concerted Role in Male Reproduction and Mitochondrial Function 96%
Similar papers in this journal
- Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad 96%
- Identification and characterization of BEND2 as a novel and key regulator of meiosis during mouse spermatogenesis 96%
- CATSPERϵ extracellular domains are essential for sperm calcium channel assembly and activity modulation 95%
Similar papers in this journal
- Distinct features in fish Bouncer proteins determine sperm-egg compatibility 95%
- NR2F2 regulation of interstitial to fetal Leydig cell differentiation in the testis: insights into differences of sex development 95%
- Structural and functional characterization of a putative de novo gene in Drosophila 94%
Similar papers in this journal
- KCTD19 associates with ZFP541 and HDAC1 and is required for meiotic exit in male mice 97%
- Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis 95%
- INO80 regulates chromatin accessibility to facilitate suppression of sex-linked gene expression during mouse spermatogenesis 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.