Siderophores can alter the population dynamics of fungal-bacterial communities by inhibiting specialized metabolism
Pham, H. T.; Kim, W.; Jang, J.; Kim, J. S.; Lim, Y. W.; Kovacs, A. T.; Kang, K. B.
Show abstract
Siderophores are microbial metabolites with a strong affinity for Fe(III) ions, in addition to other roles beyond iron acquisition. In this study, we propose that bacillibactin, a siderophore produced by the bacterium Bacillus subtilis, provides an advantage to its producer by inhibiting the specialized metabolism of antagonistic Penicillium fungi. Metabolome and transcriptome analyses indicate that iron deficiency caused by bacillibactin plays a critical role in downregulating the specialized metabolism of competing Penicillium species. Since many specialized metabolites of Penicillium spp. have antibacterial properties, we hypothesize that bacillibactin cross-protects other bacteria during fungal-bacterial community interactions. A tripartite coculture model demonstrated that bacillibactin production influences community dynamics by reducing the growth of specialized metabolite-producing Penicillium species, thereby facilitating the colonization of B. subtilis and other co-inhabiting bacterial species.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration 96%
- Glutathione metabolism impacts fungal virulence by modulating the redox environment 96%
- From iron to antibiotics: Identification of conserved bacterial-fungal interactions across diverse partners 96%
Similar papers in this journal
- Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence 95%
- Quorum sensing mediates morphology and motility transitions in the model archaeon Haloferax volcanii 95%
- A novel and conserved cell wall enzyme that can substitute for the Lipid II synthase MurG 95%
Similar papers in this journal
Similar papers in this journal
- Asymbiotic mass production of the arbuscular mycorrhizal fungus Rhizophagus clarus 96%
- Long-read metagenomics of soil communities reveals phylum-specific secondary metabolite dynamics 95%
- Targeted biomass degradation by the higher termite gut system - integrative omics applied to host and its gut microbiome 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.