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Advanced Cardiac Imaging in Treatment Decision-Making for Severe Left Ventricular Dysfunction: A Systematic Review and MetaAnalysis

Kusi-Yeboah, T.; Bally, D.; Wickramarachchi, M.; Chiu, M.; Williams, K.; Mobus, S.; Varma, A.; Bandla, A.; Taiwo, M.; Butt, H.; Sharma, A.

2025-05-13 cardiovascular medicine
10.1101/2025.05.12.25327464 medRxiv
Show abstract

This review explores whether assessing myocardial viability before coronary revascularization meaningfully impacts outcomes in patients with ischemic cardiomyopathy. By synthesizing evidence from studies employing imaging techniques such as CMR, PET, SPECT, and dobutamine stress echocardiography, we examined associations between viability status and improvements in cardiac function and survival. Our findings suggest that patients with viable myocardium tend to derive greater benefit from revascularization, particularly in terms of left ventricular recovery and reduced mortality. These results highlight the potential value of viability imaging in guiding treatment decisions and support its selective use in clinical practice.

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