A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease.
Marella, S.; Bogle, R.; Fox, J.; Tsoi, L. C.; Xing, X.; Gu, Y.; Kirma, J.; Sarkar, M. K.; van Drongelen, V.; Klein, B.; Kozlow, J. H.; Harms, P.; Gallagher, K.; Naik, S.; Rebecca, V. W.; Andersen, B.; Nakamura, M.; Kahlenberg, J. M.; Modlin, R. L.; Billi, A. C.; Gudjonsson, J. E.
Show abstract
Human skin is not a uniform organ but a mosaic of anatomically distinct niches, with each site finely tuned to unique environmental demands and immune pressures. Yet, the molecular determinants that define these regional identities and their relationship to site-specific vulnerability to inflammatory disease remain poorly understood. Here, we generate a high-resolution single-cell atlas of human skin, profiling 274,834 cells from 96 healthy samples across 7 anatomically distinct sites (acral, arm, axilla, back, face, leg and scalp). Our analysis reveals striking region-specific transcriptional and cellular networks, uncovering how local immune-stromal crosstalk governs tissue homeostasis and underpins anatomical susceptibility to distinct inflammatory diseases such as such as systemic lupus erythematosus (SLE), atopic dermatitis (AD), and psoriasis. These findings illuminate the tissue-intrinsic foundations of regional immune identity and provide a blueprint/resource for the development of precision therapies tailored to the distinct immunological microenvironments of specific anatomical skin sites.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9+ Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive Autoimmunity 96%
- Remodeling of Il4-Il13-Il5 locus underlies selective gene expression 93%
- High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation 93%
Similar papers in this journal
- Translational mapping of spatially resolved transcriptomes in human and mouse pulmonary fibrosis 94%
- Image-based spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis 93%
- Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases 93%
Similar papers in this journal
- Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients' blood 93%
- Spatial cell graph analysis reveals skin tissue organization characteristic for cutaneous T cell lymphoma 92%
- Integrative systems biology framework discovers common gene regulatory signatures in multiple mechanistically distinct inflammatory skin diseases 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.