Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming.
Shelton, M.; Anene, C. A.; Nsengimana, J.; Eldahshoury, M. K.; Keane, B.; Newton-Bishop, J. A.; Roberts, W.; Boyne, J. R.
Show abstract
Malignant melanoma has one of the lowest 5-year survival rates of any cancer, and is recognised for being particularly invasive and metastatic, with the poorest survival outcomes in brain metastases patients. A key characteristic of these tumours is crosstalk between melanoma cells and cells of the tumour microenvironment (TME), such as cancer associated fibroblasts (CAFs). The role of melanoma-derived small extracellular vesicles (sEVs) in potentiating CAFs has been studied extensively, however the role of CAF sEVs in regulation of the local TME and distal pre-metastatic niche (PMN) is less clear. Here, we demonstrate that sEVs derived from an in vitro model of melanoma CAFs alter melanoma to promote oncogenic parameters within models of the TME and target a model of the brain PMN to promote changes associated with melanoma extravasation. Cargo profiling of these sEVs found significant differential expression of proteins, and RNA associated with pre-metastatic niche remodelling and unfavourable outcomes in patients. Together these data suggest a role for CAF sEVs in local and distal PMN formation, highlighting a potential therapeutic target for metastatic melanoma and identifying prospective liquid biomarker reservoirs.
Matching journals
The top 19 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Chemokine profiling of melanoma-macrophage crosstalk identifies CCL8 and CCL15 as prognostic factors in cutaneous melanoma 95%
- Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function 91%
- Receptor for Hyaluronan-Mediated Motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients. 90%
Similar papers in this journal
- Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle 94%
- Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes 92%
- Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model 92%
Similar papers in this journal
- Phase-specific signatures of wound fibroblasts and matrix patterns define cancer-associated fibroblast subtypes 94%
- Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation 94%
- Human mammary 3D spheroid models uncover the role of filopodia in breaching the basement membrane to facilitate invasion 94%
Similar papers in this journal
- MiRNA-10b marks aggressive squamous cell carcinomas, and confers a cancer stem cell-like phenotype 93%
- PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma 93%
- Immunomodulatory effects of tumor Lactate Dehydrogenase C (LDHC) in breast cancer 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.