Enhancing Recruitment Rate and Heterogeneity in the TrialNet Pathway to Prevention Study: Insights from a Single Center Experience
Siller, A. F.; Uysal, S.; Schneider Aguirre, R.; Patel, T.; Addala, A.; Jacobsen, L. M.; Ismail, H. M.; Redondo, M. J.; Tosur, M.
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Studies to predict and prevent type 1 diabetes (T1D) are limited by small numbers and lack of participation from all affected populations. We compared TrialNet Pathway to Prevention recruitments at one pediatric center 12 months before (June 2021-May 2022, n=15) and after (June 2022-May 2023, n=319) implementation of knowledge-based interventions aimed at clinicians and participants to increase recruitment. Recruitment increased by over 20-fold, with higher enrollment for all reported races and ethnicities although the overall population was largely non-Hispanic and White. Effective interventions are still needed to overcome recruitment barriers in order to ensure that the enrolled population reflects the overall affected population.
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