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Differential effects of illness and antipsychotics on cortical thinning in first episode psychosis

2025-05-09 psychiatry and clinical psychology Title + abstract only
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IntroductionCortical grey matter loss is a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and has been shown to progress with ongoing illness. A major unresolved question concerns whether these changes are driven by the illness itself or represent iatrogenic effects of antipsychotic medication. MethodsWe report findings from a triple-blind randomised placebo-controlled MRI study where 62 antipsychotic- naive people with first episode psychosis (FEP) received...

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