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Can We Compare Attributable Risk of Adverse Events with the Self-Controlled Case Series Design in Vaccine Safety Studies? A Use Case of Guillain-Barre Syndrome

2025-05-08 public and global health Title + abstract only
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BackgroundEstimating attributable risk (AR) through self-controlled case series (SCCS) analyses alone may limit generalizability because SCCS only incorporate vaccinated patients with the outcome (e.g., Guillain-Barre syndrome [GBS]) who may differ from the overall population recommended for vaccination. ObjectiveWe aimed to demonstrate background event incidence rates impact on vaccine-specific GBS ARs and to standardize ARs across different vaccine studies by applying a generalizable, populat...

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