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Parental body mass index and offspring cardiovascular risk factors in adulthood: an intergenerational Mendelian randomization study

2025-05-07 epidemiology Title + abstract only
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ImportanceObservationally, greater pre-pregnancy maternal and paternal body mass index (BMI) are associated with a poorer offspring adult cardiovascular risk factor profile, but it is unclear whether this is due to family-level confounding or causal developmental mechanisms. ObjectiveWe aimed to test the causal effect of maternal and paternal BMI on offspring cardiovascular risk factors in adulthood, accounting for the genetic correlation between parents and offspring. DesignTwo-sample interge...

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