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Distance of covariance (DISCO), a novel measure of network homeostatic dysregulation, reveals organ system interconnections underlying mortality and disease risk
2025-05-07
geriatric medicine
Title + abstract only
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Aging manifests as the progressive declines of homeostatic resilience and repair mechanisms, marked by dysregulations across systems and increasing individual heterogeneity. However, the breadth of measures of homeostatic dysregulation remains underexplored. Here, we introduce DISCO as a novel measure of homeostatic dysregulation, integrating clinical, proteomics, metabolomics, and microbiomes data. DISCO demonstrated moderate correlation with chronological age but robustly predicted mortality, ...
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