Hippo-activated cells induce non-cell autonomous tumorigenesis in Drosophila
Honda, D.; Okumura, M.; Sakuma, C.; Ando, T.; Miura, M.; Chihara, T.
Show abstract
The Hippo pathway is known as a tumor-suppressor pathway, and most related studies have indicated that the inhibition of the Hippo pathway leads to tumorigenesis. However, recent studies have suggested that the activated Hippo pathway can potentially promote tumorigenesis in some contexts. Here, we show that the activated Hippo pathway induces non-cell-autonomous tumorigenesis characterized by tumor markers in the Drosophila wing epithelium. This suggests that the Hippo-activated cells behave similarly to "oncogenic niche cells." We found that the Hippo-activated cells distantly induced tumor-like cells exhibiting aberrant cell proliferation. Moreover, we identified the evolutionarily conserved amino acid transporters, Sat1/2, that redundantly work with the growth factors, Wingless and Spitz, for non-cell autonomous tumorigenesis. Our findings provide novel insights into the Hippo pathway and may be useful in developing cancer treatments targeting the Hippo pathway.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Tumor elimination by clustered microRNAs miR-306 and miR-79 via non-canonical activation of JNK signaling 97%
- The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth 96%
- Numb provides a fail-safe mechanism for intestinal stem cell self-renewal in adult Drosophila midgut 96%
Similar papers in this journal
- Non-apoptotic caspase activation sustains ovarian somatic stem cell functions by modulating Hedgehog-signalling and autophagy. 96%
- A single-cell transcriptome atlas of the adult muscle precursors uncovers early events in fiber-type divergence in Drosophila 96%
- Convergent Insulin and TGF-β signalling drives cancer cachexia by promoting aberrant fatbody ECM accumulation in a Drosophila tumour model 94%
Similar papers in this journal
- Temporal coordination of collective migration and lumen formation by antagonism between two nuclear receptors 95%
- Hbs and Rst adhesion molecules provide a regional code that regulates cell elimination during epithelial remodelling 95%
- Tet Controls Axon Guidance in Early Brain Development through Glutamatergic Signaling 95%
Similar papers in this journal
- Widespread non-apoptotic activation of Drosophila Caspase-2/9 limits JNK signaling, macrophage proliferation and growth of wound-like tumors 97%
- Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila 96%
- Coordination Among Multiple Receptor Tyrosine Kinase Signals Controls Drosophila Developmental Timing and Body Size 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.