A transgenic mouse allows to capture the HLA-C*06:02 immunopeptidome in a model of psoriasis
Braun, A.; Mobbs, J. I.; Chung, S.; Tuomisto, J. E.; Li, C.; Scull, K. E.; Ayala, R.; Anand, S.; Ramarathinam, S.; Kern, J. S.; Fourie, A.; McKinnon, M.; Baker, D. G.; Rao, N.; Mifsud, N. A.; Illing, P. T.; Vivian, J. P.; Rossjohn, J.; Purcell, A. W.
Show abstract
Psoriasis vulgaris is a T cell-mediated autoimmune skin condition affecting around one in fifty people worldwide. Whilst advanced immunomodulatory therapeutic options have become available in recent years, ongoing disease suppression is still required with no curative treatment available to date. The human leukocyte antigen class I allele HLA-C*06:02 is the main genetic risk determinant of psoriasis. Its function is to present peptide antigens to CD8+ T cells and natural killer cells which in turn elicit and perpetuate the immune response, yet little is known about ligands presented by HLA-C*06:02. To gain an understanding which HLA-C*06:02-restricted peptides are presented by epidermal cell populations and might be initiators of the autoimmune response in psoriasis, we have conducted an in depth immunopeptidomics analysis of HLA-C*06:02+ keratinocyte and melanocyte cell lines. Furthermore, we introduce a HLA-C*06:02 transgenic mouse which, in conjunction with the imiquimod model of psoriasis, allowed us to assess the ex vivo immunopeptidome of HLA-C*06:02 in psoriasiform skin. Overall, we detected 20,812 high confidence HLA-C*06:02 bound peptide ligands. Thus, we present a comprehensive coverage HLA-C in vitro immunopeptidomics dataset and the first HLA-C*06:02 ex vivo dataset of psoriasis-relevant peptide antigens that may inform the development of antigen-specific, novel curative therapeutic approaches in psoriasis.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Enhanced NF-κB signaling in type-2 dendritic cells at baseline predicts non-response to adalimumab in psoriasis 95%
- mRNA-delivered consensus allergens induce a neutralizing IgG response against food and pollen allergens 93%
- CD8 + T-cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A*24:02 allomorph 92%
Similar papers in this journal
- Influence of HLA class II polymorphism on predicted cellular immunity against SARS-CoV-2 at the population and individual level 95%
- In silico design of Phl p 6 variants with altered folding stability significantly impacts antigen processing, immunogenicity and immune polarization 93%
- A framework to identify antigen-expanded T Cell Receptor (TCR) clusters within complex repertoires 93%
Similar papers in this journal
- Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma 93%
- T cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin-focused, allergen-driven disease 92%
- Allergic inflammation triggers dyslipidemia via IgG signalling 92%
Similar papers in this journal
- ERAP1 allotypes 2 and 10 differentially regulate the immunopeptidome of melanocytes 97%
- Title: Abrogation and Homeostatic Restoration of IgE Responses by a Universal IgE Allergy CTL Vaccine:The Three Signal Self/Non-Self/Self (S/NS/S) Model 93%
- Identification of neoantigens in esophageal adenocarcinoma 93%
Similar papers in this journal
- Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects 93%
- Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals 92%
- A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.