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Phenotyping of virus-specific CD8+ effector T-cells over the course of primary EBV infection and the development of PTLD in renal transplant recipients.

2025-05-02 transplantation Title + abstract only
View on medRxiv
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Primary Epstein-Barr virus (EBV) infection can lead to post-transplantation lymphoproliferative disorder (PTLD) following renal transplantation (RTx). Despite EBV-driven PTLD (ePTLD) being rare, it is potentially lethal. CD8+ T-cells play a crucial role in controlling viral infections and malignant transformation of cells. We therefore hypothesized that aberrant EBV-specific CD8+ T cell maturation may contribute to ePTLD development. We performed multichannel flow cytometry on MHC class I tetram...

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