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Microglia Mitochondria Drive Neuronal Maturation via Metabolic and Transcriptional Reprogramming

Sterben, S. P.; Anamala, C. C.; Koduri, V.; Kansakar, S. B.; Liaudanskaya, V.

2025-04-30 developmental biology
10.1101/2025.04.29.651306 bioRxiv
Show abstract

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social interactions, repetitive behaviors, and disrupted neuronal circuit maturation. Emerging evidence implicates both microglial function and mitochondrial regulation as critical determinants of ASD pathogenesis. Here, we identified microglia and their mitochondria as active modulators of neuronal circuit development, highlighting their potential roles as mechanistic contributors and biomarkers in ASD progression. Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=147 SRC="FIGDIR/small/651306v1_ufig1.gif" ALT="Figure 1"> View larger version (44K): org.highwire.dtl.DTLVardef@6794ddorg.highwire.dtl.DTLVardef@5e71cborg.highwire.dtl.DTLVardef@80f0acorg.highwire.dtl.DTLVardef@138c828_HPS_FORMAT_FIGEXP M_FIG C_FIG

Matching journals

The top 11 journals account for 50% of the predicted probability mass.

1
Cell Reports
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Top 5%
6.6%
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2
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3
Molecular Psychiatry
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4
Proceedings of the National Academy of Sciences
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5.4%
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5
The FASEB Journal
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5.1%
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6
Frontiers in Cell and Developmental Biology
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Top 0.6%
4.8%
7
Journal of Neuroinflammation
○ 61 papers in training set
Top 0.3%
4.8%
8
Science Advances
● 1243 papers in training set
Top 11%
3.2%
9
Frontiers in Cellular Neuroscience
○ 91 papers in training set
Top 0.5%
2.7%
10
Nature Communications
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Top 38%
2.6%
11
American Journal of Physiology-Cell Physiology
● 39 papers in training set
Top 0.2%
2.6%
50% of probability mass above
12
eLife
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Top 42%
2.4%
13
Stem Cell Reports
○ 130 papers in training set
Top 0.9%
2.4%
14
Scientific Reports
○ 3612 papers in training set
Top 43%
2.4%
15
Glia
○ 81 papers in training set
Top 0.7%
2.1%
16
JCI Insight
● 277 papers in training set
Top 4%
2.1%
17
Translational Psychiatry
○ 260 papers in training set
Top 2%
1.9%
18
Cell Death & Disease
147 papers in training set
Top 2%
1.7%
19
Journal of Biological Chemistry
○ 690 papers in training set
Top 6%
1.5%
20
Molecular Biology of the Cell
● 311 papers in training set
Top 2%
1.5%
21
Frontiers in Molecular Neuroscience
○ 47 papers in training set
Top 0.6%
1.5%
22
PLOS ONE
● 5266 papers in training set
Top 50%
1.4%
23
Cell Communication and Signaling
○ 51 papers in training set
Top 0.6%
1.3%
24
PLOS Biology
● 486 papers in training set
Top 9%
1.0%
25
Cell Stem Cell
○ 62 papers in training set
Top 2%
1.0%
26
The FEBS Journal
○ 93 papers in training set
Top 2%
0.9%
27
Alzheimer's & Dementia
177 papers in training set
Top 2%
0.8%
28
Molecular Neurobiology
○ 53 papers in training set
Top 1%
0.8%
29
Communications Biology
○ 993 papers in training set
Top 31%
0.8%
30
EMBO Reports
○ 263 papers in training set
Top 7%
0.8%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.