Striatal signaling tracks naturalistic short-term fluctuations in hunger-satiety
Mourra, D.; Murphy, C. E.; Hourany, E.; Centeno, K.; Gnazzo, F.; Beeler, J. A.
Show abstract
The neuromodulator dopamine is integral to feeding behavior, believed to modulate food pursuit and satiety. Here, we examine how dopamine and spiny projection neurons (SPNs) signaling in the nucleus accumbens changes during consumption as animals transition from hunger to satiety in naturalistic feeding. Both dopamine and SPNs transiently increase during food approach; however, the magnitude of this approach-related increase diminishes across progressive pellet ingestion, reflecting short-term satiation. Fasting dissociates the regulation of meal size and frequency-- termination and initiation, respectively-- with altered dopamine corresponding to changes in meal size but not frequency. Despite substantially decreasing feeding, pharmacological satiation via a glucagon-like peptide-1(GLP-1) agonist had no impact on dopamine signaling, suggesting that the GLP-1 agonist disengaged or decoupled dopamine from its modulatory role in food seeking.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Dopamine in the Dorsal Bed Nucleus of Stria Terminalis signals Pavlovian sign-tracking and reward violations 96%
- An essential role for a discrete parasubthalamic nucleus subpopulation in appetite suppression 95%
- Metabolic-sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum 95%
Similar papers in this journal
- Ghrelin signalling in AgRP neurons links metabolic state to the sensory regulation of AgRP neural activity. 95%
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference 94%
- Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism. 94%
Similar papers in this journal
- Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure 95%
- Drug Reinforcement Impairs Cognitive Flexibility by Inhibiting Striatal Cholinergic Neurons 94%
- Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.