Metagenomic analysis reveals extreme complexity of Plasmodium spp. infections in high transmission in West Africa
Tan, M. H.; Bangre, O.; Rios-Teran, C. A.; Tiedje, K. E.; Deed, S. L.; Zhan, Q.; Rasyidi, F.; Pascual, M.; Ansah, P. O.; Day, K. P.
Show abstract
Mixed-species, mixed-strain Plasmodia infections are known to occur in humans in malaria endemic areas. To date, the true extent of this complexity has not been explored in high- burden countries of sub-Saharan Africa. Here we take a metagenomic lens to infections obtained by sampling variable blood volumes from residents living in high, seasonal transmission in northern Ghana. We identified significantly higher prevalence of Plasmodium spp. and inter-/intra-species complexity in larger blood volumes. Overall, malaria infections displayed high levels of metagenomic complexity comprising single-, double-, and triple- species infections with varying levels of complexity for P. falciparum, P. malariae, P. ovale curtisi, and P. ovale wallikeri. We present evidence of individuals with greater susceptibility to highly-complex infections that cannot be explained by age or location. The implications of these findings to malaria epidemiology and control are illustrated by a geographic scaling exercise to district and region levels in Ghana.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- High-resolution micro-epidemiology of parasite spatial and temporal dynamics in a high malaria transmission setting in Kenya 97%
- Genome, proteome, and immunome data explain why 6 month controlled human malaria infection with sporozoites of the Pf7G8 clone of Plasmodium falciparum is a rigorous predictor of the efficacy of the PfNF54-based PfSPZ Vaccine in Africa 95%
- Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets 95%
Similar papers in this journal
- Sensitive, highly multiplexed sequencing of microhaplotypes from the Plasmodium falciparum heterozygome 96%
- High genetic diversity of Plasmodium falciparum in the low transmission setting of the Kingdom of Eswatini 93%
- Genetic evidence of cross-border Plasmodium vivax spread in a malaria pre-elimination region of South Asia 93%
Similar papers in this journal
- Sensitive and modular amplicon sequencing of Plasmodium falciparum diversity and resistance for research and public health 97%
- Plasmodium falciparum genomic surveillance reveals spatial and temporal trends, association of genetic and physical distance, and household clustering 96%
- Identification of novel genetic variants in the malaria vaccine candidate PfRh5: structure-guided insights into potential function 96%
Similar papers in this journal
- Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination 97%
- Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia 96%
- Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.