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Persistent organic pollutant concentrations in human pancreas and peripancreatic adipose tissues correlate with markers of beta cell dysfunction

Hoyeck, M. P.; Ching, M. E. A.; Palaniyandi, J.; Fadzeyeva, E.; Kolic, J.; Ashley-Martin, J.; Lyon, J.; Smith, N.; Mulvihill, E. E.; Johnson, J. D.; Macdonald, P. E.; Bruin, J. E.

2025-04-28 toxicology
10.1101/2025.04.26.25326263 medRxiv
Show abstract

Epidemiological studies consistently report associations between circulating concentrations of persistent organic pollutants (POPs) and increased type 2 diabetes risk. Measures of POP concentrations in pancreas are limited; given the role of the endocrine pancreas in diabetes pathogenesis, this is an important gap in the literature. Additionally, no studies have correlated POP concentrations with direct measures of beta cell function in humans. We hypothesized that lipophilic POPs accumulate in human pancreas and correlate with markers of diabetes risk. To test this hypothesis, we measured POP concentration from 3 chemical classes - dioxins/furans, polychlorinated biphenyls (PCBs), and organochlorine pesticides (OCPs) - in pancreas and peripancreatic adipose tissue biopsies obtained from 31 human organ donors via the Alberta Diabetes Institute IsletCore. Indeed, POPs were consistently detected in human pancreas, and for some pollutants, at higher concentrations than in adipose. We next assessed correlations between POP concentrations and systemic indicators of diabetes risk (BMI, age, and %HbA1c) and direct measures of beta cell function. To this end, we measured insulin secretion in response to numerous secretagogues (i.e. glucose, fatty acids, amino acids, exendin-4, or KCl) in isolated islets from the same 31 donors. Pancreas PCBs and OCPs positively correlated with BMI, age and basal insulin secretion but negatively correlated with stimulation index (ratio of insulin secretion under high glucose / low glucose conditions). In contrast, pancreas dioxins/furans positively correlated with fatty acid- and amino acid-stimulated insulin secretion. These data confirm that lipophilic pollutants accumulate in human pancreas and positively correlate with markers of diabetes risk.

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