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Mendelian Randomization with longitudinal exposure data: simulation study and real data application
2025-04-26
epidemiology
Title + abstract only
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Background and aimMendelian Randomization (MR) is a widely used tool to estimate causal effects using genetic variants as instrumental variables. MR is limited to cross-sectional summary statistics of different samples and time points to analyse time-varying effects. We aimed at using longitudinal summary statistics for an exposure in a multivariable MR setting and validating the effect estimates for the mean, slope and within-individual variability. Simulation studyWe tested our approach in tw...
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