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Lack of association between G6PD variants and Parkinson's disease

2025-04-25 genetic and genomic medicine Title + abstract only
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Oxidative stress has been implicated in Parkinsons disease (PD). Genes involved in PD, such as PRKN, PINK1 and PARK7, contribute to oxidative stress in dopaminergic neurons. The X-linked G6PD gene encodes glucose 6-phosphate dehydrogenase, an important regulator of oxidative stress. Recent studies suggested that alpha-synuclein aggregates may impair G6PD activity and contribute to dopaminergic neuron loss, and that G6PD mutations may independently increase the risk of PD. In this study, we aimed...

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