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A recipient-derived macrophages subset induces kidney allograft rejection through LILRB2 signaling and CXCL10 secretion
2025-04-23
transplantation
Title + abstract only
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In solid organ transplantation, monocytes and macrophages play a cross-cutting role in the rejection process, irrespective of the transplanted tissue and the type of rejection. Here, we integrated multiple single-cell assays (>150,000 cells) with a broad spectrum of blood-derived and renal allograft-derived cells. We observed 6 myeloid cell trajectories enriched in the allograft during rejection, ranging from circulating CD14+ monocytes to differentiated macrophages in the kidney, with one traje...
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