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Glucosylation of Endogenous Haustorium-inducing factors Underpins Kin Avoidance in Parasitic Plants

Xiang, L.; Cui, S.; Saucet, S. B.; Takahashi, M.; Inaba, S.; Xie, B.; Schilder, M.; Shimada, S.; Cui, M.; Watanabe, M.; Tobimatsu, Y.; Bouwmeester, H.; Tohge, T.; Shirasu, K.; Yoshida, S.

2025-04-22 plant biology
10.1101/2025.04.17.649457 bioRxiv
Show abstract

Parasitic plants rarely attack themselves, suggesting the activity of a kin-avoidance mechanism. In the root parasitic plant Phtheirospermum japonicum, prehaustorium formation is triggered by host-secreted haustorium-inducing factors (HIFs), but it is unresponsive to its own root exudates. Here we report the identification of the spontaneous prehaustorium 1 (spoh1) mutant, which forms prehaustoria without external HIFs. spoh1 harbors a point mutation in the gene encoding UDP-glycosyltransferase GT72B1, an enzyme that glucosylates and thereby inactivates phenolic HIFs. Notably, PjGT72B1 possesses a different substrate specificity from its ortholog of the host Arabidopsis. Introduction of PjGT72B1 in Arabidopsis reduced HIF activity, indicating that HIF glucosylation regulates haustorium induction by hosts. Our findings suggest that parasitic plants have evolved kin-avoidance mechanisms through the glucosylation of endogenous HIFs.

Published in Science (predicted rank #9) · training set

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