Senescence-induced reparative fibroblasts enable scarless wound healing in aged murine skin.
Wang, D.; Wang, Z.; Yang, Y.; Bai, F.; Li, H.; He, J.; Zhou, F.; Chen, T.; Fang, T.; Wu, Z.; Zhong, J.; Xiang, L.; Man, Y.; Wu, Y.
Show abstract
It has been reported that elderly individuals exhibit reduced scarring during the wound healing process compared to younger adults. However, the underlying mechanisms responsible for this phenomenon remain poorly understood. Here, we revealed that aged mice exhibited more pronounced regenerative outcomes compared to young mice, characterized by increased hair follicle numbers and collagen fiber features closer to normal skin. Single-cell sequencing identified a reparative fibroblast subpopulation (Prss35+Fib) enriched in the aged group, which promotes regeneration through communication with epithelial cells, macrophages, and T cell subpopulations via PTN and EREG signaling. Spatial transcriptomics validated this communication pattern by elucidating cell proximity and locating the regenerative niche in the upper dermis. Finally, EREG treatment significantly enhanced regenerative outcomes in young mice, while the small wound model of aged mice, lacking the reparative fibroblast and EREG signaling, failed to achieve regeneration. Collectively, our findings advance the understanding of regenerative plasticity in aging and provide new insights for designing scarless therapeutic strategies.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions 96%
- In vivo self-renewal and expansion of quiescent stem cells from a non-human primate 96%
- Cancer associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy 95%
Similar papers in this journal
- Human brain cell-type-specific aging clocks based on single-nuclei transcriptomics 94%
- Symmetry breaking of hPSCs in micropattern generates a polarized spinal cord-like organoid (pSCO) with dorsoventral organization 94%
- Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early-Onset Colorectal Cancer 93%
Similar papers in this journal
- Space-Time Mapping Identifies Concerted Multicellular Patterns and Gene Programs in Healing Wounds and their Conservation in Cancers 96%
- The molecular anatomy of mouse skin during hair growth and rest 94%
- Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging 94%
Similar papers in this journal
- The immune landscape of murine skeletal muscle regeneration and aging 95%
- Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation 95%
- Cellular and molecular landscapes of human tendons across the lifespan revealed by spatial and single-cell transcriptomics 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.