Single cell RNA-seq discovery of blood biomarkers predicting treatment outcome in severe asthma patients

2025-04-17 respiratory medicine Title + abstract only

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Biologic monoclonal antibody therapies for severe asthma target the Type 2 endotype through blockade of the IgE, IL-5/eosinophil, or IL-4/13 pathways, which represents at least two-thirds of patients, and have led to significant clinical benefits in severe asthma management. However, studies show that 10-20% of patients may be non-responders and require a change in therapy. There is also the emerging concept that a significant percentage of patients may enter clinical remission, with a very hig...

Single cell RNA-seq discovery of blood biomarkers predicting treatment outcome in severe asthma patients

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