Chronic heart failure associates with enhanced activation and clonal expansion of T cells with predicted autoreactive capacity
Merten, M.; Rasper, T.; Holz, K.; Cremer, S.; Schuhmacher, B.; Tombor, L.; John, D.; Ullrich, E.; Macinkovic, I.; Leistner, D.; Hoffmann, J.; Speer, T.; Bonig, H.; Knosalla, C.; Potapov, E.; Sarapki, T.; Mustafic, E.; Berkowitsch, A.; Zeiher, A. M.; Dimmeler, S.; Abplanalp, W. T.
Show abstract
Chronic heart failure (HF) is characterized by adverse remodeling and persistent inflammation, contributing to impaired heart function and poor prognosis. While the acute immune response post-myocardial infarction (MI) is well-studied, its role in chronic HF remains unclear. Phenotyping of peripheral blood T cells by flow cytometry and single-cell RNA sequencing revealed T central memory cells (TCM) decline, while CD4+ Th17 and CD8+ T effector memory cells increase in HF patients compared to healthy age-matched controls. Furthermore, this decline in TCM cells and increase in homing marker CCR5 on T cell subsets associates with poor prognosis in HF. T cell receptor sequencing revealed clonal expansion in circulating and cardiac T cells, while epitope prediction modeling suggested autoreactivity of T cells in HF. Spatial and scRNA-seq data confirm inflammatory T cell infiltration in the human and murine heart post-MI. In summary, HF shows potential autoreactivity, with an increased homing capacity and declining TCM cells associated with poor prognosis.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens 96%
- Reproducing extracellular matrix adverse remodelling of non-ST myocardialinfarction in a large animal model 96%
- Single-cell transcriptome analysis reveals CD34 as a novel marker of human sinoatrial node pacemaker cardiomyocytes 95%
Similar papers in this journal
- Splenic CD169 + Tim4 + Marginal Metallophilic Macrophages Are Essential for Wound Healing After Myocardial Infarction 97%
- CD206 + IL-4Rα + MACROPHAGES ARE DRIVERS OF ADVERSE CARDIAC REMODELING IN ISCHEMIC CARDIOMYOPATHY 96%
- BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes 95%
Similar papers in this journal
- Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues 96%
- An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury 95%
- Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis 95%
Similar papers in this journal
Similar papers in this journal
- Single cell transcriptomic analysis of renal allograft rejection reveals novel insights into intragraft TCR clonality 93%
- Profile of SARS-CoV-2-specific CD4 T cell response: Relationship with disease severity and impact of HIV-1 and active Mycobacterium tuberculosis co-infection 93%
- Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.