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Association of Multiple Trait Polygenic Risk Score with Obesity and Cardiometabolic Diseases in Korean population
2025-04-16
endocrinology
Title + abstract only
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We conducted a comprehensive genetic investigation of obesity in a cohort of 93,673 Korean individuals, categorized by both body mass index and waist circumference using Korean-specific and international criteria. To explore the genetic architecture of obesity and its comorbidities, we performed genome-wide association studies and constructed polygenic risk scores (PRSs) using both conventional single trait and advanced multiple-trait models, including the PRSsum approach. Our analyses identifi...
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